Robert Rose

Biography

Dr. Rose completed a PhD at the University of Calgary (2005) and Postdoctoral Fellowship training at the University of Toronto (2005-2008) in the areas of cardiac electrophysiology and cardiac physiology. From 2008 until 2017 Dr. Rose held a faculty position in the Department of Physiology and Biophysics at Dalhousie University. 

In our laboratory we are interested in the cellular and molecular basis for cardiac arrhythmias that occur due to genetic mutations or in the setting of common forms of heart disease such as hypertension, heart failure and diabetes. Areas of particular focus include sinoatrial node dysfunction and atrial fibrillation. We are especially interested in the contributions of electrical remodeling of ion channel function as well as structural remodeling and fibrosis to changes in cardiac function. Our experimental approaches span from the cellular and molecular levels to the organ and organism levels. Our studies are performed in animal models, including wildtype and genetically modified mice, as well as in human tissues and patients.
 

Publications

PubMed

Bohne LJ, Johnson D, Rose RA, Wilton SB, Gillis AM. The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights. Front Physiol 2019;10:135.

Jansen HJ, Mackasey M, Moghtadaei M, Liu Y, Kaur J, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. NPR-C (natriuretic peptide receptor C) modulates the progression of angiotensin II-mediated atrial fibrillation and atrial remodeling in mice. Circ Arrhythmia Electrophysiol. 2019;12:e006863.

Mackasey M, Egom EE, Jansen HJ, Hua R, Moghtadaei M, Liu Y, Kaur J, McRae M, Bogachev O, Rafferty SA, Ray G, Kirkby AW, Rose RA. Natriuretic peptide receptor C (NPR-C) protects against angiotensin II mediated sinoatrial disease in mice. JACC: Bas Transl Sci 2018;3:824-843.

Jansen HJ, Mackasey M, Moghtadaei M, Belke DD, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation. J Mol Cell Cardiol 2018;124:12-25.

Jansen HJ, Moghtadaei M, Mackasey M, Rafferty S, Bogachev O, Sapp, JL, Howlett SE, Rose RA. Atrial structure, function and arrhythmogenesis in aged and frail mice. Sci Rep 2017;7:44336.

Moghtadaei M, Jansen HJ, Mackasey M, Rafferty S, Bogachev O, Sapp, JL, Howlett SE, Rose RA. The impacts of age and frailty on heart rate and sinoatrial node function. J Physiol. 2016;594:7105-7126.

Hua R, MacLeod S, Polina I, Moghtadaei M, Jansen HJ, Bogachev O, O’Blenes SB, Sapp JL, Legare JF, Rose RA. Effects of wildtype and mutant forms of atrial natriuretic peptide on atrial electrophysiology and arrhythmogenesis. Circ Arrhythm Electrophysiol. 2015;8:1240-1254.

Krishnaswamy P, Egom EE, Moghtadaei M, Jansen HJ, Azer J, Bogachev O, Mackasey M, Robbins C, Rose RA. Impaired parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice. J Mol Cell Cardiol 2015;82:125-135.

Awards

Heart and Stroke Foundation of Canada McDonald Scholarship - 2014
Heart and Stroke Foundation of Canada New Investigator Award - 2014
CIHR New Investigator Award - 2009
Heart and Stroke Foundation of Nova Scotia Greg Ferrier Award  - 2009, 2012