Xi-Long Zheng
Professor
Contact information
Location
Courses
Molecular basis of vascular biology
Research and teaching
Research areas
- Vascular smooth muscle differentiations and proliferations and vascular disease.
Biography
Dr. Zheng is a tenured professor in the Department of Biochemistry & Molecular Biology, the Libin Cardiovascular Institute of Alberta, Cumming School of Medicine at the University of Calgary. He obtained the M.D. and M.Sc. from Hunan Medical University (Central South University) in China in 1986 and 1989, respectively, and Ph.D. from the University of Calgary in 1997. He subsequently undertook postdoctoral training in the State University of New York at Stony Brook and the University of Calgary and a faculty position at the latter institution. Dr. Zheng is the recipient of many awards, including Alberta Innovates ‒ Health Solutions (AIHS) Senior Scholar Award (2008 ‒ 2015), New Investigator Award of the Heart & Stroke Foundation of Canada (2001 ‒ 2006), Scholarship Award of the Canadian Institutes of Health Research & Hypertension Society of Canada (2001 ‒ 2004), Fellowship Award of the Heart & Stroke Foundation of Canada & AstraZenica Pharma/MRC/PMAC (1999 ‒ 2001). He served on the grant panels of the Canadian Institutes of Health Research (CIHR) and Heart and Stroke Foundation of Canada (HSFC) grant panel V and is currently serving on editorial boards of several journals, including Biochemical Journal.
Publications
• Gui Y, Zheng XL. Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. J Biol Chem. 2003; 278:
• Gui Y, Zheng XL. 2-methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension. 2006; 47: 271-80.53017-25.
• Tang R-H*, Zheng XL*, Callis TE, Stansfield WE, He J, Baldwin AS, Wang D-Z, Selzman CH. Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression. Proc Natl Acad Sci USA. 2008; 105: 3362-7. * Equal contribution
• Yin H, Gui Y, Du G, Frohman MA, Zheng XL. Dependence of phospholipase d1 multi-monoubiquitination on its enzymatic activity and palmitoylation. J Biol Chem. 2010; 285: 13580-8.
• Chen J, Yin H, Jiang Y, Radhakrishnan SK, Huang ZP, Li J, Shi Z, Kilsdonk EP, Gui Y, Wang DZ, Zheng XL. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. Arterioscler Thromb Vasc Biol. 2011; 31:
• Li J, Jiang J, Yin H, Wang L, Tian R, Li H, Li D, Wang Y, Gui Y, Walsh MP, Zheng XL. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension. 2012; 60: 145-153. 368-75.
Awards
Alberta Innovates ‒ Health Solutions (AIHS) Senior Scholar Award (2008 ‒ 2015), New Investigator Award of the Heart & Stroke Foundation of Canada (2001 ‒ 2006), Scholarship Award of the Canadian Institutes of Health Research & Hypertension Society of Canada (2001 ‒ 2004), Fellowship Award of the Heart & Stroke Foundation of Canada & AstraZenica Pharma/MRC/PMAC (1999 ‒ 2001)