Ejaife Agbani

Assistant Professor

Physiology & Pharmacology

PhD - Cardiovascular Cell Biology and Pharmacology

University of Strathclyde, Glasgow, Scotland, United Kingdom, 2010

MSc - Clinical Pharmacy

University College London, England, United Kingdom, 2006

Bachelor of Pharmacy

Obafemi Awolowo University, Ile-lfe, Nigeria, 2001

Contact information

Location

Office location : HRIC3A30

Research and teaching

Research areas

  • Cell Biology of Haemostasis and Thrombosis
  • Clinical Applications of Procoagulant Membrane Dynamics
  • Haematological Innovation

Biography

Dr Agbani earned his Bachelor of Pharmacy degree (with Distinction) from Obafemi Awolowo University in Nigeria and qualified as a pharmacist. Later, he earned a Master’s in clinical pharmacy degree (with Distinction) from University College London, England. He then studied peroxynitrite chemistry and its cellular actions in pulmonary hypertension at Strathclyde University in Glasgow, Scotland where he obtained his PhD in 2010. After a post-doctoral research investigating the role of nuclear invaginations and endo-lysosomal channels in calcium signalling at the University of Edinburgh, Scotland, Dr Agbani joined the lab of Prof. Alastair Poole, at the University of Bristol, England. Here, Agbani carved out a distinct area of thrombosis (formation of blood clots) and haemostasis (arrest of bleeding) research, with his discovery through 4D advanced imaging, of a novel approach to specifically target procoagulant membrane dynamics, to control platelet driven thrombosis without blocking platelet secretions.

Dr Agbani is one of the leading authors in his field. His publications (2015-2021), in the Journal of Clinical Investigation-Insight, Blood, Scientific Reports, Haematologica, Circulation, JBC, ATVB and Platelets, have spurred a shift in thrombosis research. Dr Agbani is a member of the University of Calgary’s Cumming School of Medicine and the Libin Cardiovascular Institute. In collaboration with clinicians at the Foothills Medical Centre, Dr Agbani’s work seeks to understand the platelet biology of thrombosis in antiphospholipid syndrome during pregnancy and in hypertensive complications of pregnancies. His haematological innovation couples machine learning with the systematic quantification of platelet procoagulant membrane dynamics and is currently under tests to predict the patients that will clot or bleed more than usual after surgery. His research goal is to provide critical insights into the haemostatic response through the cell biology of thrombosis and haemostasis and to leverage this knowledge for precision medicine.


Publications

Pubmed

Research Gate

1. Agbani, E. O., et al (2021) Platelets. https://doi.org/10.1080/09537104.2021.1904133

2. Agbani, E.O., et al: (2020). Platelets. https://doi.org/10.1080/09537104.2019.1709632

3.  Agbani, E.O., et al: (2019). ArteriosclerThrombVasc Biol. https://doi.org/10.1161/ATVBAHA.119.313468

4.  Agbani, E.O., et al: (2018). Journal of Clinical Investigation-Insight. https://doi.org/10.1172/jci.insight.99062

5.  Agbani, E.O., et al: (2018). Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-17-0323

6.  Agbani, E.O., et al: (2017). Blood. https://doi.org/10.1182/blood-2017-05-787259

7.  Agbani, E.O., et al: (2017). Haematologica. https://doi.org/10.3324/haematol.2017.166819

8.  Agbani, E.O., et al: (2017) Scientific Reports. https://doi.org/10.1038/s41598-017-02933-4

9.  Agbani, E.O., et al: (2017). Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M116.746867

10. Agbani, E.O., et al: (2015). Circulation. https://doi.org/10.1161/CIRCULATIONAHA.114.015036