Libin Cardiovascular Institute of Alberta
Paul Fedak, MD, PhD is a cardiac surgeon and scientist at the University of Calgary. He is committed to the innovation and translation of new surgical therapies for patients with advanced heart disease. He has pioneered novel sternal closure techniques using Kryptonite™ adhesive and is currently developing stem cell and tissue engineering approaches to treat heart failure.
Fedak leads the surgical heart failure program at the Libin Cardiovascular Institute of Alberta and implants mechanical pump technology for patients with advanced heart failure. He is Director of the Surgical Approaches to Heart Failure Programme at the Libin Institute and is the director of the Marlene and Don Campbell Translational Research Laboratory at the University of Calgary.
Fedak graduated with honours from University of Toronto medical school and completed further training in cardiac surgery (F.R.C.S.C.) and biomedical science (Ph.D.) in Toronto. He was awarded a Detweiler Fellowship from the Royal College of Physicians and Surgeons of Canada that supported advanced training in surgery for end-stage heart disease at Northwestern University in Chicago. He was recruited to Calgary as a "Clinical Investigator" of the Alberta Heritage Foundation for Medical research (AHFMR).
He has published more than 75 peer-reviewed original manuscripts and five book chapters in this field. Dr. Fedak serves as an Invited Reviewer and/or Editorial Board Member for 16 leading biomedical publications. He is a "Distinguished Reviewer" of the Journal of Thoracic and Cardiovascular Surgery. He is the recipient of numerous international and national research awards.
Vaibhav Patel, PhD, is a basic research scientist at the University of Calgary in the department of Physiology and Pharmacology. He obtained his doctorate degree at M.S. University of Baroda, India in 2011 and then worked as a postdoctoral fellow at the University of Alberta’s department of Medicine.
During his postdoctoral training, Dr. Patel’s translational research focused on the role of ACE2/Ang 1-7 in cardiovascular disease and investigated the potential of enhancing ACE2 as a therapy for diabetic cardiovascular complications. He also investigated the novel role of adverse cytoskeletal remodeling in the progression of heart failure.
He has published more than 35 peer-reviewed manuscripts and two book chapters. Dr. Patel’s research interests lie in the role of intercellular communications in cardiac and vascular disease. His current focus is to identify the potential role of perivascular adipocyte-secreted exosomes in intercellular communications and modulation of renin-angiotensin system in the vascular smooth muscle cells and endothelial cells and their impact on vascular disease.
Robert Rose, MD, PhD, joined the University of Calgary’s faculty in January, 2017. He came to the Libin Cardiovascular Institute of Alberta from Dalhousie University's department of Physiology and Biophysics where he was on faculty from 2008 to 2017. He completed his PhD at the University of Calgary in 2005 and postdoctoral fellowship training--in the areas of cardiac electrophysiology and cardiac physiology--at the University of Toronto in 2008.
Rose’s laboratory is interested in the cellular and molecular basis for cardiac arrhythmias caused by genetic mutations or in the setting of common forms of heart disease such as hypertension, heart failure and diabetes. Areas of particular focus include sinoatrial node dysfunction and atrial fibrillation. Rose is especially interested in the contributions of electrical remodeling of ion channel function as well as structural remodeling and fibrosis to changes in cardiac function. Our experimental approaches span from the cellular and molecular levels to the organ and organism levels.